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Not responding to CHOLINE nootropics? Watch this. (hint Dopamine)

August 26, 2017 / 17 Comments



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Ok! Listen – some people will just never respond to cholinergics. Their brains really might just have a cholinergic dominance, OR not need any additional cholinergic signaling enhancements.

These folks TEND to respond better to dopamine affecting nootropics, like L-Tyrosine, Modafinil, Phenylalanine, L-Dopa, and others.

source

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17 Comments

  • Ryan Krammes

    August 26, 2017 at 1:13 am Reply

    Yes! Yes! Yes!

    I still get some benefit from Noopept but it feels a bit more like a dopaminergic to me. I also do get some vivid long term memory recall that is undeniable but the cholinergics have never done much if anything for me. I also have only once gotten what I thought might be a racetam headache (might have been unrelated) and I have never required a choline source with my racetams. I'll have to look up that choline dominance guy. BTW, if anyone is looking for a good B-supplement, I really like Thorne's B-Complex #12.

  • cj Jones

    August 26, 2017 at 1:45 pm Reply

    Thanks for this video. As always… love the information you give us!

    Have a question for you, in regards to Alpha-GPC:

    I had AWESOME experience with Alpha-GPC! LOVE THAT STUFF!

    When I discovered Apha-GPC, I experienced a HUGE increase in mental clarity, mental endurance, the ability to speak more robust and fluidly, a pronounced increase in cognitive abilities as well as physical endurance and enhanced motivation at the gym…. my body transformation has gone through the roof! Not to mention, I was nearly completely void of any mental anxiety, even when in the midst of some of life’s most stressful events.

    I But recently, I seem to have become tolerant to it. Would I be simply wasting money if I purchase CDP Choline?

    Also: will a few weeks/months of staying clear of Alph-GPC enable me to regain a level of sensitivity to it? Thanks for any response.

  • Håkon Martin Nilsen Bjerke

    October 27, 2018 at 8:22 am Reply

    I dont respond well to either. I had 250mg CDP choline and i felt pretty good, like a miild boost. But the next day the same dose did not work. I dont respond well to tyrosine either. 500mg i notice nothing and 1g i feel sick and anxious. Might wanna try Uridine.

  • Tak S

    May 3, 2019 at 11:31 pm Reply

    I’ve been on Adderall for the past year and now it’s suddenly stopped working. All i get now is an intense headache and overwhelming brain fog/confusion at any dose.
    I purchased uridine and cdp choline thinking it might help, but I experienced the same thing — headache/brain fog. Any idea on what might be going on, and what i should try?

    I’ve consulted to my doctor, but they were no help. So I’m just going to figure it out on my own.

  • The GTE Channel

    November 1, 2019 at 5:41 am Reply

    This is more a infomercial. Why can't you respond to the 16 questions below? The video raises more questions than it answers. I heard you name over twenty substances but still don't know what each of them does or what the nuances are.

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