David Sinclair’s 2022 UPDATED Supplement Protocol | And WHY He Takes It
If you’ve been following Dr David Sinclair, you know he updates his supplement protocol from time to time.
And in each interview, he gives one piece of explanation to what he does.
And certain supplements that appear in one interview, he does not mention them in other interviews.
Sometimes it’s hard to follow his protocol today.
Since, I know Sinclair’s work since 2007, before he went public in 2019.
Here, I have collected for you from a variety of sources, including Sinclair’s book, trying to figure out EVERYTHING he takes today and how much from each supplement.
And, you’ll find a very spicy comment from Sinclair about resveratrol.
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✅ Brad Stanfield vs David Sinclair on RESVERATROL
✅ David Sinclair’s Original RESVERATROL Study: Amazing Discovery & Analysis
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✅ Take longevity supplements
Resveratrol Controversy Explained
Taking Resveratrol Correctly:
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Credits: Scott Buckley
Disclaimer & Disclosure: The information in this video and/or at this channel is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge, educational and information from the research and experience of Rimon, who encourages you to make your own health care decisions based upon your research and in partnership with a qualified health care professional.
Rimon is not a medical doctor. If there is a contradiction between the advice here to your doctor or local authorities, always go with the doctor and the authorities.
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23 Comments
Otto
Great video! Thank you!!!
After having watched all your videos I'm still insecure about how much resveratrol to take (30-50mg or 500mg or even 1g like Sinclair does??)….Hopefully your forthcoming videos will help finding the right dosage…
As far as i know wheatgerms contain much more spermidine than the sources you mentioned.
Bryan Dalle Stelle
I think he updated the way he takes resveretrol. I heard ( I don't remember the interview) he now dissolves resveretrol in olive oil and a little bit of apple cider vinegar.
Wellness Messiah with Rimon
✅ Brad Stanfield vs David Sinclair on RESVERATROL
https://youtu.be/Hsk-TyjywR4
✅ David Sinclair's Original RESVERATROL Study: Amazing Discovery & Analysis
https://youtu.be/Js_l_G1x8V4
Christopher Ellis
Have been aware of D3K2 since learning that my mother died from Aortic Stenosis: calcification of the heart.
Thank you, margarine.
Res and quercetin are in my protocol
Jason B. Romano
This is another very informative video. I just recently found your channel and really enjoy the content, especially when you dive into the details of Sinclair's comments and the studies.
Since this one is about supplements, have you considered doing some videos on liposomal supplements? A lot of these longevity substances have very poor bioavailability. Using a liposomal delivery system dramatically increases the amount that gets into the bloodstream (almost all of it from what I've heard) and also facilitates entry into the cells where it is needed. I'm in the process of switching to liposomal (or phytosomes, which is very similar and does pretty much the same thing as liposomes) supplements where they are available for the stuff I take.
One last thing, Metformin is mentioned in this video, and that is not typically available to people. You've also mentioned Rapamycin on your channel I believe as a longevity molecule. It turns out there are natural mimetics of those substances. On that reasoning I added ashwagandha, EGCG, and ginseng to my stack. See the study below for scientific support:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723685/
Popel Grüner
May I add to the Spermidine question that you find HIGH concentrations of it in wheat germ. It is up to three times the concentration of mushrooms. At least that is what the web says.
A T
I would really like to clarify about Quercetin – it’s not safe to take it every day, it can damage healthy celks, and I dont think Sinclair is doing it everyday either….the study that he brings up (and I can look it up) used quercetin in hit-and-run fashion meaning 3 days in a row then 6 weeks break. Because there is no point to keep taking it everyday – once u remove senescent cells.
Schu2505
He also takes a statin for a genetic predisposition for high cholesterol. This is strange because he eats coconut yogurt, which is high in coconut oil, which is well known for raising cholesterol.
Also, the 2008 Cell study mentioned only indicates improvements in longevity in the EOD feeding and HC diet cases. In fact, in the SD (standard diet) case, lifespan was decreased with low dose of Resveratrol. (Fig 4, graph E: https://www.cell.com/cell-metabolism/pdf/S1550-4131(08)00182-4.pdf)
bernhardwalther
Great video as usual now. Thanks not to take holidays on that this summer ??
Kajt23
Great video!
CheetahBRFC
Do you think you can take berberine at night instead of metformin? Whay dose would you take if yes?
David Gifford
Once again thanks Ramon for a detailed analysis of Dr Sinclair’s stack. As I’ve mentioned before it’s not a one size fits all game. No one should follow Sinclair’s supplement stack blindly (although many seem to). Where possible measure. I’ve cut back substantially on my Vitamin D3 as my serum D-25 were high. I take 1.5g of NMN giving me good NAD+ blood levels, but I’m older than Sinclair. There was a recent study where doses over 600mg of NMN provided no additional benefit. The study didn’t mention the use of TMG at all. It seems plausible that methyl donor are needed for higher dose 500mg NMN to be beneficial. my take home from this was 1g of NMN with 500mg of TMG is sensible, taking 1.5g NMN would need 1g of TMG.
Joya Borthakur
How many of you are afraid of death??
Sandra Gallo
Muchas gracias! me encanta con la clridad que nos explicas!!! gracias muchas gracias!!!
Christopher Stebbins
Hi Rimon,
Do you address, or can you address, Berberine as an alternative to Metformin?
My doctor is not really up on longevity research, and she refused to prescribe Metformin to me. However, Berberine is touted as a natural alternative to Metformin, with many of the same benefits, plus others. Of course, I purchase Berberine online, so it's more accessible.
Thanks in advance,
Chris
Arnold Pillay
Thank you Doc… appreciate your advice
Alexander Sverdlov
Does anyone know WHERE is Sinclair taking his supplements from? Most sellers on Amazon sell fake products from noname garage companies..
DC JOHNSON
I’m an old retired scientist. I had a heart attack in my youth (65yo). I discovered Dr. Susan Brown’s work on osteoporosis. Following excellent studies she discovered 5000 IU Vitamin D+180 mcg Vitamin K2 MK 7 version is the optimal dosage to clear the arteries and organs of calcium deposits while driving the calcium into the bones where it should have been deposited if there had been sufficient vitamin D available. I have been using those exact dosages for two years in October 2022 with amazing results! I get mine in one capsule from NOW on Amazon for about $16. My cardiologist of 37 years has confirmed the calcium deposits in my carotid arteries has been reduced to insignificant levels!
Jean Weber
Thank you for your honest work! ?
Tati Ana
I don't get why he's such a guru in aging. He looks his age. He looks middle-aged. Nothing wrong with that but he's a millionaire from all his work and he doesn't look younger than his age at all.
C l Reed
Thank you!
anne thomas
I'm vegan and was wondering if iI still need b12 as I'm taken nmn and tmg
Otto
Today i saw a new video where he says that he recently only takes 500 mg NMN.